Two New Steroidal Saponins from Solanum procumbens-Reference-Cited by-同舟云学术

Two New Steroidal Saponins from Solanum procumbens

Published:2018-10 Issue:10 Volume:13 Page:1934578X1801301
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Hien Truong Thi Thu¹,Tuan Hoang Anh¹,Huong Do Phuong²,Van Luong Hoang¹,Mai Ngo Thi Tuyet¹,Tai Bui Huu³,Van Kiem Phan³⁴

Affiliation:

1. Vietnam Military Medical University, 160 Phung Hung, Phuc La, Ha Dong, Hanoi, Vietnam

2. Vietnam Military Hospital 103, 261 Phung Hung, Phuc La, Ha Dong, Hanoi, Vietnam

3. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

4. Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

Abstract

Two new steroidal saponins, solaprocumosides A (1) and B (2), and a known compound paniculonin B (3) were isolated from the aerial parts of Solanum procumbens. Their chemical structures were determined by analysis of HR-ESI-MS and NMR spectra. Compound 1 had ketone functional groups at C-16 and C-22 of sterol skeleton which is rarely found in nature. Meanwhile, compound 2 could be form by oxidative breakdown C-20/C-22 bonding of a furostane-type saponin. Compounds 1–3 showed weak cytotoxicity against HepG2 cell line with IC50 values of 55.7 ± 1.5, 48.1 ± 2.2, and 78.3 ± 2.4 μM, respectively.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801301009

Reference17 articles.

1. Anti-inflammatory and Cytotoxic Compounds from Solanum macaonense

2. Saponins from Solanum torvum and S. macaonense with Their Cytotoxic and Anti-allergic Effects

3. Peculiar steroidal saponins with opened E-ring from Solanum genera plants

4. Structures of Steroidal Alkaloid Oligoglycosides, Robeneosides A and B, and Antidiabetogenic Constituents from the Brazilian Medicinal Plant Solanum lycocarpum