Anti-inflammatory and Cytotoxic Compounds from Solanum macaonense-Reference-Cited by-同舟云学术

Anti-inflammatory and Cytotoxic Compounds from Solanum macaonense

Published:2015-02 Issue:2 Volume:10 Page:1934578X1501000
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Lee Chia-Lin¹²,Hwang Tsong-Long³⁴,Peng Chieh-Yu²⁵,Chen Chao-Jung⁶⁷,Kuo Chao-Lin⁸,Chang Wen-Yi³⁴,Wu Yang-Chang²⁵⁹

Affiliation:

1. Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan

2. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40447, Taiwan

3. Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 33302, Taiwan

4. Department of Cosmetic Science and Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33302, Taiwan

5. School of Pharmacy, College of Pharmacy, China Medical University, Taichung 40402, Taiwan

6. Graduate Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan

7. Proteomics Core Laboratory, Department of Medical Research, China Medical University Hospital, Taichung 40447, Taiwan

8. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 40402, Taiwan

9. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

Abstract

One new cerebroside, macaocerebroside A (1), and 15 known compounds (2–16) were isolated from Solanum macaonense for the first time. In an antineutrophilic inflammatory assay, four caffeic acid derivatives (2–5) were active against superoxide anion generation with IC50 values of 3.3–4.8 μM; especially, 3 inhibited elastase release with an IC50 value of 4.0 μM. Additionally, kaempferol (8) also showed inhibition against elastase release with an IC50 value of 4.0 μM. In a cytotoxic assay, rutin (14) had selective moderate cytotoxicity toward human lung (A549), bladder (NTUB1), and prostate (DU145) cancer cell lines with IC50 values of 34.6, 41.3, and 31.8 μM, respectively.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1501000235

Reference8 articles.

1. Anti-Inflammatory Spirostanol and Furostanol Saponins from Solanum macaonense

2. Structure determination and synthesis of a new cerebroside isolated from the traditional Chinese medicine Typhonium giganteum Engl.

3. Morinins H−K, Four Novel Phenylpropanol Ester Lipid Metabolites from Morina chinensis

4. Sphingolipids and glycerolipids. I. Chemical structures and ionophoretic activities of soya-cerebrosides I and II from soybean.

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