Anti-inflammatory and Anti-oxidative Activities of Polyacetylene from Dendropanax dentiger-Reference-Cited by-同舟云学术

Anti-inflammatory and Anti-oxidative Activities of Polyacetylene from Dendropanax dentiger

Published:2014-11 Issue:11 Volume:9 Page:1934578X1400901
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Chien Shih-Chang¹²,Tseng Yen-Hsueh¹,Hsu Wei-Ning¹,Chu Fang-Hua³,Chang Shang-Tzen³,Kuo Yueh-Hsiung⁴⁵,Wang Sheng-Yang¹²⁶⁷

Affiliation:

1. Department of Forestry, National Chung-Hsing University, Taichung, Taiwan

2. Experimental Forest Management Office, National Chung-Hsing University, Taichung, Taiwan

3. School of Forestry and Resource Conservation, National Taiwan University, Taipei, Taiwan

4. Graduate Institute of Chinese Pharmaceutical Science, China Medical University, Taichung, Taiwan

5. Department of Biotechnology, Asia University, Taichung, Taiwan

6. Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan

7. Agricultural Biotechnology Center, National Chung-Hsing University, Taichung, Taiwan

Abstract

Dendropanax dentiger has been used as a folk medicine since ancient times. In our current study, we observed that D. dentiger exhibited a significant anti-inflammatory activity, which could efficiently inhibit nitric oxide (NO) production in the lipopolysaccharide (LPS)-induced macrophage inflammation assay. (9 Z,16 S)-16-Hydroxy-9,17-octadecadiene-12,14-diynoic acid (HODA) was isolated from the leaves of D. dentiger following a bioactivity guided fractionation protocol. Our data indicated that HODA significantly inhibited the NO production in LPS-induced RAW 264.7 murine macrophage cells (IC50 = 4.28 μM). Consistent with these observations, the mRNA and protein expression levels of iNOS were also inhibited by HODA in a dose-dependent manner. HODA also reduced the translocation of NF-κB into nuclear fractions. Meanwhile, HODA enhanced Nrf-2 activation and its downstream antioxidant gene HO-1. We concluded that HODA possessed significant anti-inflammatory and anti-oxidative activity; the compound may have a potential for development as a chemoprevention agent.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1400901115

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