Isoflavonoids from Desmodium heterophyllum Aerial Parts-Reference-Cited by-同舟云学术

Isoflavonoids from Desmodium heterophyllum Aerial Parts

Published:2018-06 Issue:6 Volume:13 Page:1934578X1801300
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Ha Le Minh¹,Luyen Nguyen Thi²,Phuong Ngo Thi¹,Huyen Do Thi Thanh¹,Huong Le Mai¹,Quan Pham Minh¹³,Hiep Nguyen Tuan⁴,Dat Nguyen Tien²

Affiliation:

1. Institute of Natural Product Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

2. Center for Research and Technology Transfer, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

3. University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

4. Department of Extraction Technology, Vietnam National Institute of Medicinal Materials, 3B Quang Trung, Hoan Kiem, Hanoi, Vietnam

Abstract

Five isoflavanoids including one new, (3 R)–2′,4′,5,7-tetrahydroxy-6-methylisoflavanone (1), were isolated from the aerial parts of Desmodium heterophyllum. Their structures were elucidated using spectroscopic methods. Their inhibitory effects on digestive enzymes α-glucosidase and α-amylase were evaluated. Genistein (5) and dalbergioidin (2) inhibited both enzymes. Their IC50 values were found at 110.4 and 162.8 μM for α-amylase, and at 257.3 and 412.6 μM for α-glucosidase, respectively.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801300612

Reference6 articles.

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4. C-methylated and C-prenylated isoflavonoids from root extract of Desmodium uncinatum

5. Isoflavanones from Desmodium oxyphyllum and their cytotoxicity

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