A New Megastigmane Glucoside and Other Constituents from Desmodium gangeticum-Reference-Cited by-同舟云学术

A New Megastigmane Glucoside and Other Constituents from Desmodium gangeticum

Published:2020-11-04 Issue: Volume:2020 Page:1-4
ISSN:2090-9071
Container-title:Journal of Chemistry
language:en
Short-container-title:Journal of Chemistry

Author:

Dang Hau Viet¹,Do Giang Hoang¹,Ngo Phuong Thi²,Nguyen Tien Dat¹^ORCID,Le Ha Minh²^ORCID

Affiliation:

1. Center for Research and Technology Transfer, Vietnam Academy of Science and Technology (VAST), 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

2. Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

Abstract

A new megastigmane glycoside, gangeticoside (1), and three known compounds leonuriside A (2), methyl benzoate 2-O-β-D-glucopyranoside (3), and tortoside A (4) were isolated from the aerial part of Desmodium gangeticum. Their structures were determined by 1D and 2D NMR spectra. The isolated compounds were evaluated for their inhibitory effect on NO production in LPS-stimulated RAW264.7 cells. Among them, compounds 1, 2, and 3 exhibited strong effect with the IC50 values of 22.3, 15.6, 7.3 μM, respectively.

Funder

National Foundation for Science and Technology Development

Publisher

Hindawi Limited

Subject

General Chemistry

Link

http://downloads.hindawi.com/journals/jchem/2020/7416973.pdf

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