Alkaloids from an Endophytic Streptomyces sp. YIM66017-Reference-Cited by-同舟云学术

Alkaloids from an Endophytic Streptomyces sp. YIM66017

Published:2013-10 Issue:10 Volume:8 Page:1934578X1300801
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Zhou Hao¹,Yang Yabin¹,Zhang Jucheng¹,Peng Tianfeng¹,Zhao Lixing²,Xu Lihua²,Ding Zhongtao¹

Affiliation:

1. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China

2. Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, China

Abstract

Three alkaloids, flavensomycinoic acid (1), a linear polyketide, alpiniamide (2), and cyclo (L-Trp-L-Ala) (3), were isolated from the culture filtrate of endophytic Streptomyces sp. YIM66017 from Alpinia oxyphylla. Their structures were elucidated by spectroscopic analysis and the structure of 1 was confirmed by X-ray crystallographic analysis. Compound 1 was isolated from a natural source for the first time, and compound 2 is a new compound. Compound 1 showed cytotoxicity to MCF-7 with an IC 50 value of 17.0 μM.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1300801012

Reference14 articles.

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