Therapeutic Potential of Endophytic Compounds: A Special Reference to Drug Transporter Inhibitors
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Published:2019-07-19
Issue:10
Volume:19
Page:754-783
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ISSN:1568-0266
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Container-title:Current Topics in Medicinal Chemistry
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language:en
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Short-container-title:CTMC
Author:
Singh Khusbu1, Dwivedi Gaurav Raj1, Sanket A. Swaroop1, Pati Sanghamitra1
Affiliation:
1. Microbiology Department, ICMR-Regional Medical Research Centre, Bhubaneswar, India
Abstract
From the discovery to the golden age of antibiotics (miracle), millions of lives have been saved. The era of negligence towards chemotherapeutic agents gave birth to drug resistance. Among all the regulators of drug resistance, drug transporters are considered to be the key regulators for multidrug resistance. These transporters are prevalent from prokaryotes to eukaryotes. Endophytes are one of the unexplored wealths of nature. Endophytes are a model mutualistic partner of plants. They are the reservoir of novel therapeutics. The present review deals with endophytes as novel drug resistance reversal agents by inhibiting the drug transporters across the genera. This review also focuses on drug transporters, and mutualistic chemical diversity, exploring drug transporter modulating potential of endophytes.
Funder
Science & Engineering Research Board
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
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