A New Benzofuran Derivative From the Stems of Helicteres hirsuta-Reference-Cited by-同舟云学术

A New Benzofuran Derivative From the Stems of Helicteres hirsuta

Published:2019-06 Issue:6 Volume:14 Page:1934578X1985881
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Tra Nguyen Thanh¹,Ha Nguyen Thi Thu¹,Cham Ba Thi¹,Anh Le Thi Tu¹,Yen Le Thi Hai²,Giang Bach Long³,Anh Dang Thi Tuyet¹,Tuyen Nguyen Van¹,Kiem Phan Van⁴⁵

Affiliation:

1. Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam

2. Hanoi Medical College, Hanoi, Vietnam

3. NTT Hi-Tech Insitute, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam

4. Institute of Marine Biochemistry, VAST, Hanoi, Vietnam

5. Graduate University of Science and Technology, VAST, Hanoi, Vietnam

Abstract

A new benzofurane 7-methoxy-2-(3-hydroxy-4-methoxyphenyl)-benzofuran-5-carboxylate (1) and 5 known compounds, such as propacin (2), hisbiscolatone A (3), heliclactone (4), rosmarinic acid (5), and syringaldehyde (6), were isolated from methanol extract of the Helicteres hirsuta stems. Their structures were elucidated by spectroscopic analysis as Nuclear Magnetic Resonance (NMR) and Mass Spectroscopy (MS) Furthermore, compounds 1 to 6 were evaluated for their cytotoxic activity against 4 human cancer cell lines such as Lu-1, MCF7, HepG2, and KB. The results showed that compound 2 exhibited moderate cytotoxic activity against Lu-1, MCF7, HepG2, and KB cell lines with IC50 values of 43.97 ± 2.12, 46.53 ± 0.75, 52.63 ± 0.24, and 56.37 ± 1.04 µg/mL, respectively. This is the first report of compounds 2 to 6 from H. hirsuta.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X19858814

Reference23 articles.

1. Medicinal plants: An important asset to health care in a region of Central Laos

2. Antinociceptive activity of Helicteres isora

3. Vo VC. Dictionary of common plants. Hanoi, Vietnam: Hanoi Science and Technology Publishing House. 2004;2:1349-1350.

4. Flowering Plants

5. Cytotoxic Triterpenoids from the Root Bark ofHelicteres angustifolia

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Coumarin as an Elite Scaffold in Anti-Breast Cancer Drug Development: Design Strategies, Mechanistic Insights, and Structure–Activity Relationships;Biomedicines;2024-05-27

2. α-Glucosidase inhibition of sesquiterpenoids from the heartwood of Mansonia gagei;Phytochemistry;2023-09

3. Application of Rosmarinic Acid with Its Derivatives in the Treatment of Microbial Pathogens;Molecules;2023-05-22

4. A Comprehensive Review of Rosmarinic Acid: From Phytochemistry to Pharmacology and Its New Insight;Molecules;2022-05-20

5. Antioxidant Constituents from the Stem and Leaf of Helicteres hirsuta Loureiro;The Natural Products Journal;2021-10