Sesquiterpenoid Lactones in Tanacetum huronense Inhibit Human Glioblastoma Cell Proliferation-Reference-Cited by-同舟云学术

Sesquiterpenoid Lactones in Tanacetum huronense Inhibit Human Glioblastoma Cell Proliferation

Published:2016-05 Issue:5 Volume:11 Page:1934578X1601100
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Dissanayake Amila A.¹,Bejcek Bruce E.²,Zhang Chuan-Rui¹,Nair Muraleedharan G.¹³

Affiliation:

1. Bioactive Natural Products and Phytoceuticals Laboratory, Department of Horticulture, Michigan State University, East Lansing, Michigan, 48824, USA

2. Department of Biological Sciences, Western Michigan University, 1903 W. Michigan Ave., Kalamazoo, MI 49008, USA

3. College of Food and Agriculture Sciences, Chair of Date Palm Research, King Saud University, Riyadh, 11451, Saudi Arabia

Abstract

Tanacetum huronense (Lake Huron tansy), which is native to the upper Midwest region of USA and Canada, was examined for the presence of anticancer compounds using an in vitro human tumor cell proliferation inhibition assay, with glioblastoma derived cell line U-87 MG. Bioassay-directed purification of the ethyl acetate extract of the aerial portion of this plant identified six active sesquiterpenoid lactones (1–6). Among these, compounds 5 and 6 are new structural analogs. One of the most abundant isolates, tanacin (4), exhibited the greatest inhibition with an IC50 value of 4.5 μg/mL.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1601100504

Reference23 articles.

1. A chemotaxonomic study of endemic species of genus Tanacetum from the Canary Islands

2. Harvest Regimen Optimization and Essential Oil Production in Five Tansy (Tanacetum vulgare L.) Genotypes under a Northern Climate

3. Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases

4. Immunomodulatory activity of acidic polysaccharides isolated from Tanacetum vulgare L.

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A review of natural products and small‐molecule therapeutics acting on central nervous system malignancies: Approaches for drug development, targeting pathways, clinical trials, and challenges;Drug Development Research;2024-04-29