Charantoside L, A New Cucurbitane-Type Glycoside from Momordica charantia L. with α-Glucosidase Inhibitory Activities-Reference-Cited by-同舟云学术

Charantoside L, A New Cucurbitane-Type Glycoside from Momordica charantia L. with α-Glucosidase Inhibitory Activities

Published:2022-01 Issue:1 Volume:17 Page:1934578X2110689
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Yen Duong Thi Hai¹,Yen Pham Hai¹²,Hop Nguyen Quang³,Hung Nguyen Anh³,Tran Ha Thi Thu⁴⁵,Huu Tai Bui¹²,Nhiem Nguyen Xuan¹²,Van Kiem Phan¹²^ORCID

Affiliation:

1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam

2. Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam

3. Hanoi Pedagogical University 2, Vinhphuc, Vietnam

4. Institute of Forestry Research and Development (IFRAD), Thai Nguyen University of Agriculture and Forestry, Thai Nguyen City, Vietnam

5. Thai Nguyen University of Agriculture and Forestry, Thai Nguyen City, Vietnam

Abstract

A new cucurbitane-type glycoside (1) and two known compounds (2-3) were isolated from the ethanol extract of the fruits of Momordica charantia L. Their chemical structures were determined as (19 S,23 E)-5 β,19-epoxy-19-methoxycucurbita-6,23-diene-3 β,25-diol 3 -O-β-D-allopyranoside (1), goyaglycoside d (2), and (19 S,23 E)-5 β,19-epoxy-19-methoxycucurbita-6,23-diene-3 β,25-diol (3) on the basis of the extensive spectroscopic methods, including 1D, 2D NMR, HRESIMS, and in comparison with the reported data. Compounds 1 to 3 were evaluated for α-glucosidase inhibitory effects. Compounds 1 and 2 showed anti α-glucosidase activity with IC50 values of 134.12 ± 11.20 and 163.17 ± 13.71 µM, respectively, compared with the positive control, acarbose, IC50 160.99 ± 14.30 μM. Compounds 2 and 3 were first isolated from plant M. charantia growing in Vietnam.

Funder

Vietnam Academy of Science and Technology

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X211068924

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