Two New Sterol Sulfates from Marine Spider Conch Lambis Lambis Linnaeus, 1758

Abstract

Two new (1 and 2) and six known (3-8) compounds were isolated from the methanolic extract of the Vietnamese marine spider conch Lambis lambis Linnaeus, 1758. Based on comprehensive spectroscopic analyses, particularly HRESIMS, and 1D- and 2D-NMR spectra, their chemical structures were determined to be 25,26,27-tri-nor-cholest-5-ene-2 β,3 α,24-triol-2,24-disulfate (1), 25,26,27-tri-nor-cholesta-2 β,3 α,24-triol-3,24-disulfate (2), 25,26,27-tri-nor-cholesta-2β,3α,24-triol-2,3,24-trisulfate (solomonsterol A, 3), 1- O-arachidonoyl-3- O-stearylglycerol (4), eicosapentaenoic acid (5), adenosine (6), adenine (7), and uracil (8). This is the first report of compounds 3-8 from L. lambis.