Affiliation:
1. Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji'nan, 250012, Shandong, China
Abstract
Genome sequence analysis of Streptomyces sp. LZ35 has revealed a large number of secondary metabolite pathways, including a hybrid fatty acid-type PKS gene cluster for biosynthesis of galbonolides. By sequence-guided and culture medium selection and with the aid of specific staining on TLC, galbonolides B (1) and E (2) have been identified from strain Streptomyces sp. LZ35. Further discovery and mining of galbonolides from a clean background mutant strain, Streptomyces sp LZ35Δheng (SR107), led to the isolation of galbonolides F (3) and G (4), which were elucidated by analysis of their HRESIMS and NMR spectroscopic data.
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine
Cited by
1 articles.
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