Acetylenic Terrestrial Anticancer Agents-Reference-Cited by-同舟云学术

Acetylenic Terrestrial Anticancer Agents

Published:2006-05 Issue:5 Volume:1 Page:1934578X0600100
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Dembitsky Valery M¹,Levitsky Dmitri O²

Affiliation:

1. Department of Medicinal Chemistry and Natural Products, School of Pharmacy, P.O. Box 12065, The Hebrew University of Jerusalem, Jerusalem 91120, Israel

2. CNRS UMR 6204, Biotechnologie, Biocatalyse et Biorégulation, Faculté des Sciences et des Techniques, Université de Nantes, P.O. Box 92208, 44322 Nantes Cedex 3, France

Abstract

Acetylenic metabolites belong to a class of molecules containing triple bond(s). They are found in plants, fungi, microorganisms, and marine invertebrates. This review presents 139 active acetylenic molecules of plant, fungal, and soil bacterial origin that reveal cytotoxic and/or anticancer activities. Although many compounds of this group possess encouraging characteristics, they have never been evaluated as potential anticancer agents. They are of great interest, especially for the medicine and/or pharmaceutical industries. Here we describe structures and biological activities of acetylenic metabolites.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X0600100512

Reference290 articles.

1. LamJ, BretelerH, ArnasonA, HansenH. (Eds). (1988) Chemistry and Biology of Naturally-Occurring Acetylenes and Related Compounds, Elsevier, Amsterdam, pp. 366

2. Natural Medicine:The Genus Angelica

3. Natural acetylenes of special biosynthetic interest

4. Biochemical systematics and fungi

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