Bioactive Compounds Isolated from Indonesian Epiphytic Plant of Sarang Semut and Their Antibacterial Activity against Pathogenic Oral Bacteria

Author:

Kurnia Dikdik1,Sumiarsa Dadan1,Dharsono Hendra D.A.2,Satari Mieke H.3

Affiliation:

1. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran Jl. Raya Bandung-Sumedang Km. 21, Jatinangor45363, Indonesia

2. Department of Conservative Dentistry, Faculty of Dentistry, Universitas Padjadjaran Jl. Raya Bandung-Sumedang Km. 21, Jatinangor45363, Indonesia

3. Department of Oral Biology, Faculty of Dentistry, Universitas Padjadjaran Jl. Raya Bandung-Sumedang Km. 21, Jatinangor45363, Indonesia

Abstract

A new phenolic compound (1), a steroid (2), a new steroid glycoside (4), two triterpenoids (3 & 6) and a new phloroglucinol-sesquiterpene (5) have been isolated from the ethyl acetate extract of Sarang Semut ( Myrmecodia pendans) and their structures were determined on the basis of the spectral data. The bioactivity evaluation was conducted with the inhibition zone of compounds (mm) using Kirby-Bauer method at concentrations of 1000 and 5000 ppm for compound 1 against pathogenic oral bacteria Enterococcus faecalis, was 8.55 and 8.05 mm, respectively. Compounds 2–3 against Streptococcus mutans were 9.00 and 8.45 mm (2) and 10.24 and 9.35 mm (3), respectively. Compound 5 against Porphyromonas gingivalis was 11.5 and 10.8 mm, respectively.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Reference26 articles.

1. Herbs in dentistry

2. Anticancer Activity Test for Extracts of Sarang Semut Plant (Myrmecodya pendens) to HeLa and MCM-B2 Cells

3. SubrotoM.A., Saputro. (2008) Gempur Penyakit dengan Sarang Semut. Penebar Swadaya Press, Jakarta, 11–32 (in Indonesian).

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