Author:
Primasari Ameta,Apriyanti Eti,Ambardhani Nurul,Satari Mieke Hemiawati,Herdiyati Yetty,Kurnia Dikdik
Abstract
Background:
Dental diseases are generally caused by oral bacteria such as Enterococcus faecalis, Streptococcus mutans, and Streptococcus sanguinis. These bacteria have resistance to synthetic drugs; thus, it is required to discover new antibacterial agents. Sarang Semut (Myrmecodia pendans) has been empirically used as a medicinal plant to treat various conditions, including those caused by pathogenic bacteria.
Objective:
The present study was aimed to investigate the antibacterial activity of Sarang Semut extracts against E. faecalis, S. mutans, and S. sanguinis.
Materials and Methods:
Sarang Semut was extracted with several solvents to yield n-hexane, ethyl acetate, methanol, and water extracts. Each extract and combination were adjusted for assay with chlorhexidine, fosfomycin, and quercetin and used as positive controls.
Results:
The n-hexane extract showed activity with inhibition zone values of 7.15 and 10.45 ppm against E. faecalis and S. mutans at 1%, respectively. All combination extracts could inhibit the growth of E. faecalis and S. sanguinis. The synergistic effects resulting from the combination of extract-fosfomycin were also presented in this evaluation, with the strongest shown by water-fosfomycin against S. mutans, with inhibition zones of 28.5 mm at 1%.
Conclusion:
Sarang Semut extracts demonstrated antibacterial activity against oral pathogenic bacteria. These results offer alternative natural sources for the new antibacterial drug candidate.
Publisher
Bentham Science Publishers Ltd.
Reference57 articles.
1. Yon MJY, Gao SS, Chen KJ, Duangthip D, Lo ECM, Chu CH.
Medical model in caries management.
Dent J
2019;
7
(2)
: 37.
2. Marsh PD, Martin MV, Lewis MAO, Williams DW.
Oral Microbiology 5th ed.
2009;
222.
3. Frías-Muñoz M, Araujo-Espino R, Martínez-Aguilar VM, Alcalde TC, Aguilera-Galaviz LA, Gaitán-Fonseca C.
Aggressive periodontitis and its multidisciplinary focus: Review of the literature. Odovtos - Int.
J Dent Sci
2017;
19
(3)
: 27.
4. Nazir MA.
Prevalence of periodontal disease, its association with systemic diseases and prevention.
Int J Health Sci (Qassim)
2017;
11
(2)
: 72-80.
5. Damayanti L, Evaangelina IA, Laviana A, Herdiyati Y, Kurnia D.
Antibacterial activity of Buah Merah (Pandanus conoideus Lam.) against bacterial oral pathogen of Streptococcus sanguinis ATCC10556, Streptococcus mutans ATCC 25175, and Enterococcus faecalis ATCC 29212: An in vitro Study.
Open Dent J
2020;
14
(1)
: 113-9.
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