Two New Oleanane-type Triterpenoids from Methanolyzed Saponins of Momordica cochinchinensis-Reference-Cited by-同舟云学术

Two New Oleanane-type Triterpenoids from Methanolyzed Saponins of Momordica cochinchinensis

Published:2016-06 Issue:6 Volume:11 Page:1934578X1601100
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Fan Rong¹²,Cheng Rong-Rong¹,Zhu Hong-Tao¹,Wang Dong¹,Yang Chong-Ren¹,Xu Min¹,Zhang Ying-Jun¹

Affiliation:

1. State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China

2. Yunnan University of Traditional Chinese Medicine, Kunming, 650500, P. R. China

Abstract

Two new oleanane-type triterpenoid saponins (1 and 2) were isolated from the methanolyzed total saponins of the seeds of Momordica cochinchinensis (Lour.) Spreng, together with 16 known compounds (3—18). Their structures were elucidated on the basis of detailed spectroscopic, including ID and 2D NMR, mass spectrometric, methanolysis and LC-MS analysis. All the isolates were tested for their cytotoxic activities against five human cancer cell lines (HL-60, SMMC-7721, PANC-1, A-549, and SW-480) and the glucose uptake activity. The known compound 6 exhibited toxic effects against HL-60 with an IC50 value of 18.1 μM, while 10 showed cytotoxicity against SMMC-7721 and A-549 cell lines, with IC50 values of 34.4 and 32.8 μM, respectively. In addition, the new compound 2 showed glucose uptake activity with a glucose consumption value of 0.29 μM at 10 μM concentration.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1601100607

Reference15 articles.

1. Studies on the constituents of Momordica cochinchinensis Spreng. I. Isolation and characterization of the seed saponins, momordica saponins I and II.

2. Studies on the constituents of Momordica cochinchinensis Spreng. II. Isolation and characterization of the root saponins, Momordins I, II and III.

3. Structural characterization and identification of five triterpenoid saponins isolated from Momordica cochinchinensis extracts by liquid chromatography/tandem mass spectrometry

4. Phytochemicals and antioxidant activity of different fruit fractions (peel, pulp, aril and seed) of Thai gac (Momordica cochinchinensis Spreng)

5. Inhibitory Mechanisms of Oleanolic Acid 3-O-Monodesmosides on Glucose Absorption in Rats.

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