Affiliation:
1. Key Laborarory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China
2. School of Traditional Chinese Materia Media, Shenyang Pharmaceutical University, 110016, Shenyang, P. R. China
3. Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University, 150086, Harbin, P. R. China
Abstract
Investigations of the constituents of the stem barks of Garcinia xanthochymus have yielded two new compounds, garcinenones X (1) and Y (2), along with five known xanthones, 1,4,5,6-tetrahydroxy-7-(3-methylbut-2-enyl)xanthone (3), 1,4,6-trihydroxy-5-methoxy-7-(3-methylbut-2-enyl)xanthone (4), 1,4,5,6-tetrahydroxy-7,8-di(3-methylbut-2-enyl)xanthone (5), 1,3,5,6-tetrahydroxy-4,7,8-tri(3-methylbut-2-enyl)xanthone (6), and 1,5,6-trihydroxy-7,8-di(3-methylbut-2-enyl)-6′,6'dimethylpyrano(2′,3′:3,4)xanthone (7). The structures of the compounds were determined by spectroscopic methods. The cell growth inhibitory activity of the isolated compounds against the PC-3 cell line was measured. Among them, compounds 2, 3, 5, and 6 exhibited significant inhibitory effects with IG50 values of 14.3, 15.5, 11.1, and 6.8 μM, respectively.
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine
Cited by
9 articles.
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