Polyisoprenylated Acylphloroglucinols from Garcinia nervosa-Reference-Cited by-同舟云学术

Polyisoprenylated Acylphloroglucinols from Garcinia nervosa

Published:2018-03 Issue:3 Volume:13 Page:1934578X1801300
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Nugroho Alfarius Eko¹,Nakamura Hitomi¹,Inoue Daisuke¹,Hirasawa Yusuke¹,Wong Chin Piow¹,Kaneda Toshio¹,Hadi A. Hamid A.²,Morita Hiroshi¹

Affiliation:

1. Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142–8501, Japan

2. Department of Chemistry, Faculty of Science, University Malaya, 50603 Kuala Lumpur, Malaysia

Abstract

Two new polyisoprenylated acylphloroglucinols, 7- epi-isoxanthochymol and 7- epi-cycloxanthochymol (1 – 2), were isolated from the barks of Garcinia nervosa together with their 7-epimers isoxanthochymol (3) and cycloxanthochymol (4). Their structures were determined on the basis of NMR spectroscopic data. The cytotoxic activity of the isolated compounds against HL-60, MCF-7 (human breast adenocarcinoma), A549 (human lung adenocarcinoma) and HepG2 (human hepatocellular carcinoma) cells were evaluated, and all compounds showed cytotoxic activity against all cell lines.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801300324

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