Xanthones from Garcinia Propinqua Roots

Author:

Meesakul Pornphimol1,Pansanit Acharavadee1,Maneerat Wisanu1,Sripisut Tawanun2,Ritthiwigrom Thunwadee3,Machan Theeraphan1,Cheenpracha Sarot4,Laphookhieo Surat1

Affiliation:

1. Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand

2. School of Cosmetic Science, Mae Fah Luang University, Chiang Rai 57100, Thailand

3. Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand

4. School of Science, University of Phayao, Phayao 56000, Thailand

Abstract

Phytochemical investigation of Garcinia propinqua roots led to the isolation and identification of a new xanthone, doitunggarcinone D (1), together with 15 known compounds (2–16). Their structures were elucidated by intensive analysis of spectroscopic data. Compounds 3, 6, 7, 14, 15 and 16 exhibited strong antibacterial activity against Bacillus subtilis TISTR 088 with MIC values in the range of 1–4 μg/mL. Compounds 3, 7, 10 and 14 also showed good antibacterial activity against B. cereus TISTR 688 with MIC values ranging from 4–8 μg/mL.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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