The Influence of Duration of Circulatory Arrest at 20°C on Cerebral Changes

Author:

Fisk G. C.1,Wright J. S.1,Hicks R. G.1,Anderson R. McD.1,Turner B. B.1,Baker W. de C.1,Lawrence J. C.1,Stacey R. B.1,Lawrie G. M.1,Kalnins I.1,Rose Margaret1

Affiliation:

1. Departments of Anaesthesia, Cardiothoracic Surgery, Neurology and Paediatrics, The Prince Henry and the Prince of Wales Hospitals, Sydney, the Schools of Paediatrics and Surgery, University of New South Wales, and the Department of Pathology, University of Melbourne

Abstract

In infants and piglets subjected to periods of circulatory arrest at 20°C there was close correlation between duration of arrest and delay in return of electroencephalographic activity. Post mortem studies demonstrated histological evidence of brain damage in patients after circulatory arrest at 20°C. Similar histological changes were demonstrated in piglets, including some who had complete E.E.G. and clinical recovery from circulatory arrest.

Publisher

SAGE Publications

Subject

Anesthesiology and Pain Medicine,Critical Care and Intensive Care Medicine

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