1. Department of Pharmacology and Toxicology, University of Kuopio, Kuopio, Finland;
2. Orion Pharma, Department of Pharmacokinetics, Turku, Finland;
3. Department of Pharmaceutics, University of Kuopio, Kuopio, Finland;
4. Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland