Affiliation:
1. ECVAM (European Centre for the Validation of Alternative Methods), JRC Environment Institute, 21020 Ispra (Va), Italy
Abstract
ECVAM's role in the practical validation of replacement alternative methods for use in regulatory testing is reviewed, including an outline of the criteria which have been used in determining ECVAM's priorities. Some of the difficulties which have arisen in validation studies are discussed, and solutions to these are proposed, with particular emphasis on ensuring that methods are sufficiently well-developed to enter the validation process, and on the ECVAM prevalidation scheme for encouraging protocol optimisation and the prior assessment of interlaboratory transferability. Comments are made on problems encountered in selecting test materials backed by adequate in vivo data and in undertaking appropriate in vivo/in vitro comparisons.
Subject
Medical Laboratory Technology,Toxicology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference28 articles.
1. Anon. (1986). European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes. 51 pp. Strasbourg: Council of Europe.
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