Buccal and Percutaneous Absorptions-Reference-Cited by-同舟云学术

Buccal and Percutaneous Absorptions

Published:1971-02 Issue:2 Volume:5 Page:38-41
ISSN:0012-6578
Container-title:Drug Intelligence & Clinical Pharmacy
language:en
Short-container-title:Drug Intelligence & Clinical Pharmacy

Author:

Lien Eric¹,Koda Robert T.¹,Tong George L.¹

Affiliation:

1. School of Pharmacy, University of Southern California, Los Angeles, 90007.

Abstract

Buccal absorption of 31 aromatic and aliphatic acids and 10 basic drugs in human subjects has been found to be parabolically dependent on the log P, where P is the l-octanol-water partition coefficient. The ideal lipophilic character (log Po) for maximum buccal absorption is found to range from 4.2 to 5.5. The log of the permeability constant of a series of alcohols and steroids has been found to be linearly dependent upon the log of the partition coefficient measured in three different solvent systems.

Publisher

SAGE Publications

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics

Link

http://journals.sagepub.com/doi/pdf/10.1177/106002807100500202

Reference19 articles.

1. Some Physico-Chemical Factors in Drug Action

2. Mechanisms of Drug Absorption and Distribution

3. Renal disposal of salicyluric acid

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