Low-dose Gabapentin for Intractable Hiccups in a Heart Transplant Recipient

Author:

Page Robert L.1,Luna Megan1,Brieke Andreas1,Lindenfeld JoAnn1

Affiliation:

1. University of Colorado (RLP, AB, JL), University of Colorado Hospital (ML), Aurora

Abstract

Intractable hiccups can be a serious complication in transplant recipients. Unfortunately, many of the pharmacotherapies used to stop hiccups are associated with severe side effects as well as drug-drug interactions with immunosuppressants. We report a case of a heart transplant recipient who had had intractable hiccups for 2 months, resulting in severe insomnia, diminished appetite, and weight loss. To treat the hiccups, treatment with oral baclofen (5–10 mg 3 times daily) was started. After 6 weeks of therapy, the baclofen was titrated down and discontinued because it had not stopped the hiccups and was causing severe central nervous system side effects. Gabapentin (100 mg twice daily) was then prescribed and within 24 hours of the start of that treatment, the hiccups had resolved completely. After 3 weeks of therapy, the patient had no side effects and the gabapentin was subsequently discontinued. One year after stopping the gabapentin, the patient remains free of hiccups. Gabapentin appears to be a promising medication for the treatment of intractable hiccups in thoracic transplant recipients because of its lack of serious side effects at low doses, rapid onset of action, and lack of drug-drug interactions with transplant medications.

Publisher

SAGE Publications

Subject

Transplantation

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Systematic Review: Treatment for Addictive Disorder in Transplant Patients;The American Journal on Addictions;2020-05-14

2. Chronic Hiccups;Anesthesia & Analgesia;2017-10

3. Gabapentin Therapy of Hiccups;Annals of Pharmacotherapy;2013-05-14

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