Affiliation:
1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
Abstract
Contact sites are areas of close apposition between two membranes that coordinate nonvesicular communication between organelles. Such interactions serve a wide range of cellular functions from regulating metabolic pathways to executing stress responses and coordinating organelle inheritance. The past decade has seen a dramatic increase in information on certain contact sites, mostly those involving the endoplasmic reticulum. However, despite its central role in the secretory pathway, the Golgi apparatus and its contact sites remain largely unexplored. In this review, we discuss the current knowledge of Golgi contact sites and share our thoughts as to why Golgi contact sites are understudied. We also highlight what exciting future directions may exist in this emerging field.
Funder
European Molecular Biology Organization
Deutsche Forschungsgemeinschaft
Dr. Gilbert Omenn and Martha Darling Professorial Chair in Molecular Genetics
Subject
General Materials Science
Cited by
16 articles.
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