Role of Diacylglycerol in PKD Recruitment to the TGN and Protein Transport to the Plasma Membrane-Reference-Cited by-同舟云学术

Role of Diacylglycerol in PKD Recruitment to the TGN and Protein Transport to the Plasma Membrane

Published:2002-01-11 Issue:5553 Volume:295 Page:325-328
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Baron Carole L.¹,Malhotra Vivek¹

Affiliation:

1. Section of Cell and Developmental Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

Protein kinase D (PKD) is a cytosolic serine-threonine kinase that binds to the trans-Golgi network (TGN) and regulates the fission of transport carriers specifically destined to the cell surface. PKD was found to bind diacylglycerol (DAG), and this binding was necessary for its recruitment to the TGN. Reducing cellular levels of DAG inhibited PKD recruitment and blocked protein transport from the TGN to the cell surface. Thus, a DAG-dependent, PKD-mediated signaling regulates the formation of transport carriers from the TGN in mammalian cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference24 articles.

1. Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain.

2. Recruitment of protein kinase D to the trans-Golgi network via the first cysteine-rich domain

3. Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester

4. Essential role for diacylglycerol in protein transport from the yeast Golgi complex

5. Yeast Sec14p Deficient in Phosphatidylinositol Transfer Activity Is Functional In Vivo

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