The Molecular Biology of Mucosal Field Cancerization of the Head and Neck

Author:

Ha Patrick K.1,Califano Joseph A.1

Affiliation:

1. The Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, 818 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205;

Abstract

Field cancerization was first described in 1953 as histologically altered epithelium surrounding tumor samples taken from the upper aerodigestive tract. Since then, the term has been used to describe multiple patches of pre-malignant disease, a higher-than-expected prevalence of multiple local second primary tumors, and the presence of synchronous distant tumors within the upper aerodigestive tract. Molecular techniques such as karyotype analysis, microsatellite analysis, p53 mutation screening, and X-chromosome inactivation studies have further refined the relationship among these lesions. While there are differences in the techniques used to identify the clonal origins of the lesions, these studies indicate that there is often lateral clonal spread of pre-malignant or malignant disease, and a significant portion of local second primary tumors are in fact genetically related. Distant second primary tumors found in the esophagus are often not related to concurrent head and neck cancer, whereas synchronous squamous lung tumors with a head and neck primary are often, in fact, metastases, rather than independently arising malignancies. These observations help to explain the high incidence of recurrent disease, despite excision or other therapy—pre-malignant or malignant clones often have the ability to migrate and persist outside of the field of treatment. Therefore, alternative means of prevention or therapy that can affect the entire head and neck region may be of benefit to such patients. Future studies will further refine the relationship among these lesions and perhaps identify key molecular alterations to be used as targets for gene therapy.

Publisher

SAGE Publications

Subject

General Dentistry,Otorhinolaryngology

Reference42 articles.

1. Chromosomal Aneuploidy Precedes Morphological Changes and Supports Multifocality in Head and Neck Lesions

2. Chemoprevention of Head and Neck Cancer

3. Bedi GC, Westra WH, Gabrielson E, Koch W, Sidransky D (1996). Multiple head and neck tumors: evidence for a common clonal origin. Cancer Res 56:2484–2487.

4. Methodology for Evaluating the Incidence of Second Primary Cancers with Application to Smoking-relted Cancers from the Surveillance, Epidmiology, and End Results (SEER) Program

5. Boyle JO, Hakim J, Koch W, van der Riet P, Hruban RH, Roa RA, et al. (1993). The incidence of p53 mutations increases with progression of head and neck cancer. Cancer Res 53:4477–4480.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3