Directional sensitivity of the cerebral pressure-flow relationship during forced oscillations induced by oscillatory lower body negative pressure

Author:

Labrecque Lawrence12,Roy Marc-Antoine12,Soleimani Dehnavi Shahrzad12,Taghizadeh Mahmoudreza12,Smirl Jonathan D34567ORCID,Brassard Patrice12ORCID

Affiliation:

1. Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada

2. Research center of the Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada

3. Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Canada

4. Concussion Research Laboratory, Faculty of Health and Exercise Science, University of British Columbia, Kelowna, BC, Canada

5. Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada

6. Hotchkiss Brain Institute, University of Calgary, Calgary, Canada

7. Integrated Concussion Research Program, University of Calgary, Calgary, Canada

Abstract

A directional sensitivity of the cerebral pressure-flow relationship has been described using repeated squat-stands. Oscillatory lower body negative pressure (OLBNP) is a reproducible method to characterize dynamic cerebral autoregulation (dCA). It could represent a safer method to examine the directional sensitivity of the cerebral pressure-flow relationship within clinical populations and/or during pharmaceutical administration. Therefore, examining the cerebral pressure-flow directional sensitivity during an OLBNP-induced cyclic physiological stress is crucial. We calculated changes in middle cerebral artery mean blood velocity (MCAv) per alterations to mean arterial pressure (MAP) to compute ratios adjusted for time intervals (ΔMCAvT/ΔMAPT) with respect to the minimum-to-maximum MCAv and MAP, for each OLBNP transition (0 to −90 Torr), during 0.05 Hz and 0.10 Hz OLBNP. We then compared averaged ΔMCAvT/ΔMAPT during OLBNP-induced MAP increases (INC) (ΔMCAvT/[Formula: see text]) and decreases (DEC) (ΔMCAvT/[Formula: see text]). Nineteen healthy participants [9 females; 30 ± 6 years] were included. There were no differences in ΔMCAvT/ΔMAPT between INC and DEC at 0.05 Hz. ΔMCAvT/[Formula: see text] (1.06 ± 0.35 vs. 1.33 ± 0.60 cm⋅s−1/mmHg; p = 0.0076) was lower than ΔMCAvT/[Formula: see text] at 0.10 Hz. These results support OLBNP as a model to evaluate the directional sensitivity of the cerebral pressure-flow relationship.

Publisher

SAGE Publications

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