MOG-antibody-associated longitudinal extensive myelitis after ChAdOx1 nCoV-19 vaccination-Reference-Cited by-同舟云学术

MOG-antibody-associated longitudinal extensive myelitis after ChAdOx1 nCoV-19 vaccination

Published:2021-12-21 Issue: Volume: Page:135245852110575
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Dams Larissa¹^ORCID,Kraemer Markus²^ORCID,Becker Jana¹

Affiliation:

1. Alfried Krupp Hospital, Essen, Germany

2. Alfried Krupp Hospital, Essen, Germany; Heinrich-Heine-University of Düsseldorf, Düsseldorf, Germany

Abstract

This case report describes a 59-year-old man with myelin oligodendrocyte glycoprotein (MOG)-positive longitudinal extensive transverse myelitis (LETM) after being vaccinated with the COVID-19 vaccine ChAdOx1 nCoV-19. He presented with urinary retention, gait disturbance, hypoesthesia and brisk reflexes in his lower extremities without paresis. Due to the ineffectiveness of high-dose intravenous methylprednisolone, therapeutic plasma exchange was performed, gradually improving the patient’s condition. Vaccination as a trigger for an excessive immunological response seems plausible, though unspecific for the ChAdOx1 nCoV-19 vaccine.

Publisher

SAGE Publications

Subject

Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1177/13524585211057512

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