Triterpene Tetraglycosides From <i>Stichopus Herrmanni</i> Semper, 1868-Reference-Cited by-同舟云学术

Triterpene Tetraglycosides From Stichopus Herrmanni Semper, 1868

Published:2022-05 Issue:5 Volume:17 Page:1934578X2211053
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Vien Le Thi¹,Hanh Tran Thi Hong¹,Quang Tran Hong¹,Thanh Nguyen Van¹,Thao Do Thi²^ORCID,Cuong Nguyen Xuan¹,Nam Nguyen Hoai¹,Thung Do Cong³,Van Kiem Phan¹^ORCID

Affiliation:

1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam

2. Institute of Biotechnology, VAST, Hanoi, Vietnam

3. Institute of Marine Environment and Resources, VAST, Haiphong, Vietnam

Abstract

Using various column chromatographic methods, 5 triterpene tetraglycosides (1−5), including one new compound, namely holothurin A6 (1), were obtained from the water soluble part of the methanol extract of the sea cucumber Stichopus herrmanni. Their structures were confirmed by careful analysis of the 1D and 2D NMR, and HR ESI QTOF mass spectra. Noteworthily, 24-dehydroechinoside A (3) showed potent cytotoxicity to 5 human cancer cell lines {HepG2 (hepatoma cancer), KB (epidermoid carcinoma), LNCaP (prostate cancer), MCF7 (breast cancer), and SK-Mel2 (melanoma)} with IC50 values ranging from 0.19 ± 0.03 to 1.17 ± 0.18 µM.

Funder

Vietnam Academy of Science and Technology

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X221105369

Reference13 articles.

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2. Cytotoxic triterpene saponins from Cercodemas anceps

3. Cytotoxic triterpene diglycosides from the sea cucumber Stichopus horrens

4. Triterpene tetraglycosides from the sea cucumber Stichopus horrens

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3. Herrmananes A and B, two new sulfated hydrocarbons from the sea cumber Stichopus herrmanni;Vietnam Journal of Chemistry;2022-09-21