3-O-(3′-Hydroxytetradecanoyl)lupeol from Sorocea trophoides Inhibits Cruzain-Reference-Cited by-同舟云学术

3-O-(3′-Hydroxytetradecanoyl)lupeol from Sorocea trophoides Inhibits Cruzain

Published:2007-09 Issue:9 Volume:2 Page:1934578X0700200
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Richter Lori R.¹,Vogler Bernhard¹,Penton Ashley F.¹,Setzer William N.¹,Haber William A.²,Caffrey Conor R.³,Hansell Elizabeth³,McKerrow James H.³

Affiliation:

1. Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA

2. Missouri Botanical Garden, St. Louis, Missouri 63166, USA Apdo. 50–5655, Monteverde, Puntarenas, Costa Rica

3. Tropical Disease Research Unit, Department of Pathology, University of California San Francisco, VAMC, 4150 Clement Street-113B, San Francisco, California 94121, USA

Abstract

The crude chloroform extract from the stem bark of Sorocea trophoides (Moraceae) showed in-vitro inhibition of the cysteine protease cruzain. Activity-directed fractionation led to isolation of the novel 3- O-(3′-hydroxytetradecanoyl)lupeol as the inhibitory agent. The structure was elucidated by analysis of NMR spectra.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X0700200902

Reference15 articles.

1. Chemotherapy of Chagas Disease: Status and New Developments

2. Phenothiazine Inhibitors of Trypanothione Reductase as Potential Antitrypanosomal and Antileishmanial Drugs

3. The Crystal Structure of Cruzain: A Therapeutic Target for Chagas' Disease

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