Prenylated Isoflavonoids from Rhynchosia edulis-Reference-Cited by-同舟云学术

Prenylated Isoflavonoids from Rhynchosia edulis

Published:2011-11 Issue:11 Volume:6 Page:1934578X1100601
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Ogungbe Ifedayo V.¹,Hill Gabrielle M.¹,Crouch Rebecca A.¹,Vogler Bernhard¹,Nagarkoti Meenakshi¹,Haber William A.²,Setzer William N.¹

Affiliation:

1. Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA

2. Missouri Botanical Garden, St. Louis, Missouri 63166, USA; Apdo 50-5655, Monteverde, Puntarenas, Costa Rica

Abstract

Four new prenylated isoflavones, rhynedulins A-C (1-3) and rhynedulinal (4), were isolated by bioassay-guided fractionation of the dichloromethane bark extract of Rhynchosia edulis. Five previously described compounds, scandenal, ulexin B, cajanone, cajanin, and cyclochandalone, were also isolated. These isoflavonoids showed weak inhibitory activity towards rhodesain, the major cathepsin-L like protease in Trypanosoma brucei. They also have weak antiproliferative activity towards MCF-7 cells.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1100601119

Reference32 articles.

1. Secondary root growth in Rhynchosia edulis Griseb. (Leguminosae): Origin of cambia and their products

2. C-glycosylflavones from Rhynchosia minima

3. Tirumalin, a new prenylated dihydroflavonol from Rhynchosia cyanosperma

4. Flavone O- and C-glycosides of Rhynchosia beddomei

5. C-prenylated dihydroflavonol from Rhynchosia densiflora

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