Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients-Reference-Cited by-同舟云学术

Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients

Published:2010-07 Issue:3 Volume:7 Page:213-215
ISSN:1479-1641
Container-title:Diabetes and Vascular Disease Research
language:en
Short-container-title:Diabetes and Vascular Disease Research

Author:

Nassimizadeh Mohammad¹,Ashrafian Houman²,Drury Nigel E³,Howell Neil J³,Digby Janet²,Pagano Domenico⁴,Frenneaux Michael P⁵,Born Gustav VR⁶

Affiliation:

1. Cardiovascular Medicine Group, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

2. Department of Cardiovascular Medicine, University of Oxford, Oxford, UK

3. Cardiovascular Medicine Group, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK, Department of Cardiothoracic Surgery, University Hospital Birmingham, Birmingham, UK

4. Department of Cardiothoracic Surgery, University Hospital Birmingham, Birmingham, UK

5. University of Aberdeen, Polwarth Building, UK,

6. William Harvey Research Institute, University of London, London, UK

Abstract

Reduced endothelial surface charge markedly increases the rate of LDL uptake into blood vessels. Previous work in the streptozotocin diabetic rat reported reduced endothelial surface charge. We compared endothelial surface charge density in internal mammary artery rings from patients with type 2 diabetes (n = 12) and from non diabetic patients undergoing coronary artery bypass grafting, and observed a substantial (52%) reduction in the former. This was associated with higher plasma sialic acid levels suggesting loss of sialic acid residues from the glycocalyx as a possible mechanism.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1479164110376207

Reference6 articles.

1. Increasing Cardiovascular Disease Burden Due to Diabetes Mellitus

2. Reduced negative surface charge on arterial endothelium of diabetic rats

3. Hypothesis: arterial glycocalyx dysfunction is the first step in the atherothrombotic process

4. Endothelial Glycocalyx Damage Coincides With Microalbuminuria in Type 1 Diabetes

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Endothelial Glycocalyx;Comprehensive Physiology;2022-08-23

2. Human glycocalyx shedding: Systematic review and critical appraisal;Acta Anaesthesiologica Scandinavica;2021-03-07

3. Glycocalyx sialic acids regulate Nrf2-mediated signaling by fluid shear stress in human endothelial cells;Redox Biology;2021-01

4. The role of sialic acids in the initiation of atherosclerosis;Minerva Cardioangiologica;2020-10

5. The need to freeze—Dehydration during specimen preparation for electron microscopy collapses the endothelial glycocalyx regardless of fixation method;Microcirculation;2020-07-26