Cutting Edge: Impaired Glycosphingolipid Trafficking and NKT Cell Development in Mice Lacking Niemann-Pick Type C1 Protein

Author:

Sagiv Yuval,Hudspeth Kelly,Mattner Jochen,Schrantz Nicolas,Stern Randi K.,Zhou Dapeng,Savage Paul B.,Teyton Luc,Bendelac Albert

Publisher

The American Association of Immunologists

Subject

Immunology,Immunology and Allergy

Reference41 articles.

1. The Structure and Function of the Niemann–Pick C1 Protein

2. The NPC1 protein: structure implies function

3. Patterson, M. C., M. T. Vanier, K. Suzuki, J. A. Morris, E. D. Carstea, E. B. Neufeld, et al 2001. Neimann-Pick disease C: a lipid trafficking disorder. C. R. Scriver, and A. Beaudet, and W. S. Sly, and D. Valle, eds. The Metabolic and Molecular Bases of Inherited Disease 2625-2639. McGraw-Hill, New York.

4. A defect in cholesterol esterification in Niemann-Pick disease (type C) patients.

5. The intracellular transport of low density lipoprotein-derived cholesterol is defective in Niemann-Pick type C fibroblasts.

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