Affiliation:
1. Institut Imagine, INSERM UMR1163 Paris Cité University France
2. Aligning Science Across Parkinson's (ASAP) Collaborative Research Network Chevy Chase MD USA
3. Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research University of Tübingen Germany
Abstract
Glycolipid balance is key to normal body function, and its alteration can lead to a variety of diseases involving multiple organs and tissues. Glycolipid disturbances are also involved in Parkinson's disease (PD) pathogenesis and aging. Increasing evidence suggests that glycolipids affect cellular functions beyond the brain, including the peripheral immune system, intestinal barrier, and immunity. Hence, the interplay between aging, genetic predisposition, and environmental exposures could initiate systemic and local glycolipid changes that lead to inflammatory reactions and neuronal dysfunction. In this review, we discuss recent advances in the link between glycolipid metabolism and immune function and how these metabolic changes can exacerbate immunological contributions to neurodegenerative diseases, with a focus on PD. Further understanding of the cellular and molecular mechanisms that control glycolipid pathways and their impact on both peripheral tissues and the brain will help unravel how glycolipids shape immune and nervous system communication and the development of novel drugs to prevent PD and promote healthy aging.
Funder
H2020 European Research Council
Michael J. Fox Foundation for Parkinson's Research
Subject
General Biochemistry, Genetics and Molecular Biology