CTLA-4 Overexpression Inhibits T Cell Responses through a CD28-B7-Dependent Mechanism
Author:
Publisher
The American Association of Immunologists
Subject
Immunology,Immunology and Allergy
Reference51 articles.
1. Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
2. Thymocyte development is normal in CTLA-4-deficient mice
3. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
4. CTLA-4 can function as a negative regulator of T cell activation
5. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.
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