5. Microdose Clinical Study for Drug Development
Author:
Affiliation:
1. Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Publisher
Japanese Society of Clinical Pharmacology and Therapeutics
Subject
Pharmacology (medical),Pharmacology
Link
http://www.jstage.jst.go.jp/article/jscpt/41/1/41_1_27/_pdf
Reference16 articles.
1. 1) Kola I and Landis J. Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov. 2004; 3: 711-5.
2. 2) Frank R and Hargreaves R. Clinical biomarkers in drug discovery and development. Nat Rev Drug Discov. 2003; 2: 566-80.
3. 3) Grass GM and Sinko PJ. Physiologically-based pharmacokinetic simulation modelling. Adv Drug Deliv Rev. 2002; 54: 433-51.
4. 4) Chiba M, Ishii Y and Sugiyama Y. Prediction of hepatic clearance in human from in vitro data for successful drug development. Aaps J. 2009; 11: 262-76.
5. 5) Maeda K and Sugiyama Y. In vitro-in vivo scale-up of drug transport activities. You G and Morris ME (Eds). Drug transporters. New Jersey: John Wiley & Sons, Inc., 2007: 557-88.
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