Clinical biomarkers in drug discovery and development
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd1130.pdf
Reference168 articles.
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3. Yuan, R. P. et al. In vitro metabolic interaction studies: Experience of the Food and Drug Administration. Clin. Pharmacol. Ther. 66, 9–15 (1999).
4. Schadt, E. E., Monks, S. A. & Friend, S. H. A new paradigm for drug discovery: integrating clinical genetic, genomic and molecular phenotype data to identify drug targets. Biochem. Soc. Trans. 31, 437–443 (2003). Discussion of the potential value in a drug discovery setting of combining genetic analyses with gene expression studies to discover and validate therapeutic targets for complex phenotypic traits. This approach will also be applicable to the search for biomarkers.
5. van de Vijver, M. et al. A gene expression signature as a predictor of survival in breast cancer. N. Engl. J. Med. 347, 1999–2009 (2002). Expression patterns of 70 genes revealed 2 signatures correlating clearly with good and poor prognosis independently of axillary lymph node involvement. This study has important lessons for the clinical and investigational use of microarray approaches in oncology today.
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