The Nephroprotective Effects of Moringa Oleifera Extract against Contrast Induced Nephrotoxicity

Abstract

Objectives: The present research has been conducted  to assess the Nephroprotective effects of the Moringa Oleifera Extract against contrast -induced nephrotoxicity in  male rabbits. Study Design: Experimental design Place and Duration of Study: it was carried out in the Faculty of Pharmacy/University of Kufa, Iraq/Al-Najaf Town .The study began at October 2020 and end at March 2021. Methodology: Twenty one adult (male rabbits) weighing range(1.2-1.5kg). Rabbits are divided in a random manner into three equal groups each group including seven rabbits. Group1:control group administered DW, Group2:has been treated with Iodide contrast(2.5mg/kg) of (370mg/ml),group 3: dosed alcoholic extracts of Moringa 250 mg/kg and contrast (2.5mg/kg).By accounting data on the MDA levels ,Glutathione level and features of kidney histopathology. All efforts have been made to reduce the suffering of a  animals prior to and throughout the experiment and sampling. Results: The alcoholic Moringa extract at 250mg/kg body weight doses orally considerably protected contrast induced toxicity of the kidneys in the rabbits through the increment of the level of  GSH and reduces the level of MDA. In the Histological data, the extract activities also protect the damage of the kidney, which is induced by the contrast that has been represented by the de-generation of some tubules and atrophy of glomerular, glomerular tuft congestion and expanded Bowman’s Space. Conclusions: This study proposed that Moringa’s alcoholic extract results in the enhancement of the defense status of the oxidative stress against the renal toxicity.(Moringa Oleifera have Nephroprotective effect against contrast induce Nephrotoxicity).