LC–MS/MS determination of apixaban (BMS-562247) and its major metabolite in human plasma: an application of polarity switching and monolithic HPLC column
Author:
Affiliation:
1. Bristol-Myers Squibb, Route 206 Province Line Road, Lawrenceville, NJ 08543, USA
2. Intertek Pharmaceutical Services, 1100 Windfield Way, El Dorado Hills, CA 95762, USA
Abstract
Publisher
Future Science Ltd
Subject
Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry
Link
http://www.future-science.com/doi/pdf/10.4155/bio.14.66
Reference23 articles.
1. An overview of various validated HPLC and LC-MS/MS methods for quantitation of drugs in bile: challenges and considerations
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3. Recent advances in high-throughput quantitative bioanalysis by LC–MS/MS
4. Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa
5. Apixaban: A New Player in the Anticoagulant Class
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