Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa-Reference-Cited by-同舟云学术

Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Published:2007-10-03 Issue:22 Volume:50 Page:5339-5356
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pinto Donald J. P.¹,Orwat Michael J.¹,Koch Stephanie¹,Rossi Karen A.¹,Alexander Richard S.¹,Smallwood Angela¹,Wong Pancras C.¹,Rendina Alan R.¹,Luettgen Joseph M.¹,Knabb Robert M.¹,He Kan¹,Xin Baomin¹,Wexler Ruth R.¹,Lam Patrick Y. S.¹

Affiliation:

1. Discovery Chemistry, Research and Development, Bristol-Myers Squibb Company, 31 Pennington-Rocky Hill Road, Pennington, New Jersey 08534

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm070245n

Reference64 articles.

1. The International Normalized Ratio

2. Low-Molecular-Weight Heparins

Cited by 378 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Investigation of the structural and thermodynamic properties of the inclusion complex of apixaban with natural cyclodextrins;Journal of Molecular Structure;2024-12

2. The U.S. FDA approved cardiovascular drugs from 2011 to 2023: A medicinal chemistry perspective;European Journal of Medicinal Chemistry;2024-09

3. Minimally modified human blood coagulation factor X to bypass direct factor Xa inhibitors;Journal of Thrombosis and Haemostasis;2024-08

4. An alternative synthetic strategy to construct apixaban analogues;Arkivoc;2024-07-07

5. Design and synthesis of novel factor XIa Inhibitors with bicyclic isoquinoline and naphthalene fragments;Medicinal Chemistry Research;2024-05-30