Biotransformation and biocatalysis: roles and applications in the discovery of antimalarials-Reference-Cited by-同舟云学术

Biotransformation and biocatalysis: roles and applications in the discovery of antimalarials

Published:2012-12 Issue:18 Volume:4 Page:2325-2336
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Chigorimbo-Murefu Nyaradzo TL¹,Njoroge Mathew¹,Nzila Alexis²,Louw Stefan¹,Masimirembwa Collen³,Chibale Kelly⁴

Affiliation:

1. Department of Chemistry & Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa

2. Department of Chemistry, King Fahd University of Petroleum & Minerals, PO Box 468 Dhahran, 31261, Saudi Arabia

3. African Institute of Biomedical Science & Technology, Dominion House, 211 Herbert Chitepo Street, Harare, Zimbabwe

4. Department of Chemistry & Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa.

Abstract

Several strategies to discover new antimalarials have been proposed to augment and complement the conventional drug-discovery paradigm. One approach, which has not yet been fully exploited, is the use of drug biotransformation to identify new active molecules. This concept rests on the use of the biotransformation of drugs to their pharmacologically active metabolites. This approach has been used successfully in human chemotherapy, with the discovery and development of several metabolite-based drugs. This review looks at the contribution that biotransformations can play in antimalarial drug discovery.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

http://www.future-science.com/doi/pdf/10.4155/fmc.12.173

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