Latest progress in the development of cyclooxygenase-2 pathway inhibitors targeting microsomal prostaglandin E<sub>2</sub> synthase-1-Reference-Cited by-同舟云学术

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Latest progress in the development of cyclooxygenase-2 pathway inhibitors targeting microsomal prostaglandin E₂ synthase-1

Published:2022-03 Issue:6 Volume:14 Page:385-388
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

LaBorde Krista¹,Lu Renzhong¹^ORCID,Ruan Ke-He¹^ORCID

Affiliation:

1. Center for Experimental Therapeutics & Pharmacoinformatics & Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77004, USA

Funder

National Institutes of Health

American Heart Association

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/fmc-2021-0317

Reference26 articles.

1. Pharmacological Inhibition of Microsomal Prostaglandin E Synthase-1 Suppresses Epidermal Growth Factor Receptor-Mediated Tumor Growth and Angiogenesis

2. Identification and development of mPGES-1 inhibitors: where we are at?

3. Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs

4. Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics

5. Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily

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