Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics-Reference-Cited by-同舟云学术

Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics

Published:2015-05-20 Issue:11 Volume:58 Page:4727-4737
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Luz John Gately¹,Antonysamy Stephen¹,Kuklish Steven L.²,Condon Bradley¹,Lee Matthew R.¹,Allison Dagart¹,Yu Xiao-Peng²,Chandrasekhar Srinivasan²,Backer Ryan²,Zhang Aiping¹,Russell Marijane¹,Chang Shawn S.¹,Harvey Anita²,Sloan Ashley V.²,Fisher Matthew J.²

Affiliation:

1. Lilly Biotechnology Center San Diego, 10300 Campus Point Drive, Suite 200, San Diego, California 92121, United States

2. Lilly Research Laboratories, Lilly Corporate Center, 355 East Merrill Street, Indianapolis, Indiana 46285, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00330

Reference44 articles.

1. Acetaminophen (paracetamol) is a selective cyclooxygenase‐2 inhibitor in man

2. The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase