Small molecules as central nervous system therapeutics: old challenges, new directions, and a philosophic divide-Reference-Cited by-同舟云学术

Small molecules as central nervous system therapeutics: old challenges, new directions, and a philosophic divide

Published:2019-03 Issue:6 Volume:11 Page:489-493
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Banks William A¹²,Greig Nigel H³

Affiliation:

1. Geriatric Research Education & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA

2. Division of Gerontology & Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA

3. Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/fmc-2018-0436

Reference18 articles.

1. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

2. Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes

3. CNS Physicochemical Property Space Shaped by a Diverse Set of Molecules with Experimentally Determined Exposure in the Mouse Brain

4. The function of tight junctions in maintaining differences in lipid composition between the apical and the basolateral cell surface domains of MDCK cells.

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