CNS Physicochemical Property Space Shaped by a Diverse Set of Molecules with Experimentally Determined Exposure in the Mouse Brain
Author:
Affiliation:
1. Eli Lilly and Company, 893 South Delaware Street, Indianapolis, Indiana 46285, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01469
Reference48 articles.
1. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
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5. Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes
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