Experimental free ligand conformations: a missing link in structure-based drug discovery
Author:
Affiliation:
1. Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, UK
2. Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, UK
Publisher
Future Science Ltd
Subject
Drug Discovery,Pharmacology,Molecular Medicine
Link
https://www.future-science.com/doi/pdf/10.4155/fmc-2018-0339
Reference20 articles.
1. The role of dynamic conformational ensembles in biomolecular recognition
2. Conformational control in structure-based drug design
3. Importance of Rigidity in Designing Small Molecule Drugs To Tackle Protein–Protein Interactions (PPIs) through Stabilization of Desired Conformers
4. Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors
5. Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP)
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