2,5-disubstituted bicyclo[2.1.1]hexanes as rigidified cyclopentane variants-Reference-Cited by-同舟云学术

2,5-disubstituted bicyclo[2.1.1]hexanes as rigidified cyclopentane variants

Published:2023 Issue:30 Volume:14 Page:8070-8075
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Paul Shashwati¹,Adelfinsky Daniel¹,Salome Christophe²^ORCID,Fessard Thomas²,Brown M. Kevin¹^ORCID

Affiliation:

1. Department of Chemistry, Indiana University, 800 E. Kirkwood Ave, Bloomington, IN 47405, USA

2. SpiroChem AG, Rosental Area, WRO-1047-3, Mattenstrasse 22, 4058 Basel, Switzerland

Abstract

Identification of rigid counterparts for common flexible scaffolds is crucial to the advancement of medicinal chemistry. Herein, synthesis of new bicyclo[2.1.1]hexanes to act as rigidified cyclopentanes is described.

Funder

National Institute of General Medical Sciences

Indiana University

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC02695G

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