A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor
Author:
Affiliation:
1. Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland
2. PIQUR Therapeutics AG, Hochbergerstrasse 60, 4057 Basel, Switzerland
Funder
Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung
Kommission f?r Technologie und Innovation
Stiftung zur Krebsbek?mpfung
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00972
Reference49 articles.
1. Lipid signalling in disease
2. mTOR kinase structure, mechanism and regulation
3. Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex
4. Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase
5. Phosphoinositide 3-kinase in disease: timing, location, and scaffolding
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