Toward the elucidation of the mechanism for passive membrane permeability of cyclic peptides
Author:
Affiliation:
1. ETH Zurich, Department of Chemistry & Applied Biosciences, Vladimir-Prelog-Weg 2, 8093 Zurich, Switzerland
Publisher
Future Science Ltd
Subject
Drug Discovery,Pharmacology,Molecular Medicine
Link
https://www.future-science.com/doi/pdf/10.4155/fmc-2018-0429
Reference20 articles.
1. Cyclic peptide therapeutics: past, present and future
2. Converting a Peptide into a Drug: Strategies to Improve Stability and Bioavailability
3. The mechanism of action of cyclosporin A and FK506
4. Conformational Flexibility, Internal Hydrogen Bonding, and Passive Membrane Permeability: Successful in Silico Prediction of the Relative Permeabilities of Cyclic Peptides
5. Kinetic Models of Cyclosporin A in Polar and Apolar Environments Reveal Multiple Congruent Conformational States
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3. Addressing Challenges of Macrocyclic Conformational Sampling in Polar and Apolar Solvents: Lessons for Chameleonicity;Journal of Chemical Information and Modeling;2023-11-09
4. Lessons for Oral Bioavailability: How Conformationally Flexible Cyclic Peptides Enter and Cross Lipid Membranes;Journal of Medicinal Chemistry;2023-02-10
5. Polar/apolar interfaces modulate the conformational behavior of cyclic peptides with impact on their passive membrane permeability;RSC Advances;2022
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